HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → Ethyl 3-(2-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-(2-chlorobenzoyl)-N-[(3-thienylcarbonyl)methyl]amine | HCID 13105429 | — |
| Product | Ethyl 3-(2-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate | HCID 13105433 | 97.3% |
Reaction Steps
11.0 g of N-(2-chlorobenzoyl)-N-[(3-thienylcarbonyl)methyl]amine, 2.17 g of 50% sodium hydride and 7.9 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(4). 14 g of ethyl 3-(2-chlorobenzoylamino)-3-(3-thienylcarbonyl)propionate are thereby obtained as an oil. Yield: 97.2%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04460596 |
| Source dataset | uspto-grants-1984_07 |
| ORD ID | ord-9c647141016341b9ad6b974b7591f7be |
| Source note | uspto-grants-1984_07 |