Sodium Hydroxide → 5-(4-Methyl-1-piperazinyl)-11H-imidazo(1,2-C)(1,3)benzodiazepine

HRID 1462449Notes

Reaction equation

HRID 1462449 reaction equation
[C:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:18]3[CH:19]=[CH:20][N:21]=[C:17]3[CH2:16][C:15]3[CH:22]=[CH:23][CH:24]=[CH:25][C:14]=3[N:13]=2)[CH2:8][CH2:7]1)(OCC)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1>[CH3:1][N:6]1[CH2:7][CH2:8][N:9]([C:12]2[N:18]3[CH:19]=[CH:20][N:21]=[C:17]3[CH2:16][C:15]3[CH:22]=[CH:23][CH:24]=[CH:25][C:14]=3[N:13]=2)[CH2:10][CH2:11]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 133449165-(4-ethoxycarbonyl-1-piperazinyl)-11H-imidazo[1,2-c][1,3]benzodiazepineHCID 21226445Aluminium lithium hydride

Product 1

HCID 133449095-(4-Methyl-1-piperazinyl)-11H-imidazo(1,2-C)(1,3)benzodiazepine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 0.2 g of 5-(4-carboethoxy-1-piperazinyl)-11H-imidazo[1,2-c][1,3]benzodiazepine in 2 ml of dry tetrahydrofuran, 100 mg of lithium aluminum hydride are added at once and the mixture is refluxed under nitrogen for 48 hours. The mixture is cooled to room temperature, stirred with 0.2 ml of 30% sodium hydroxide, and filtered. The filtrates are evaporated to dryness and the product is purified to give 5-(4-methyl-1-piperazinyl)-11H-imidazo[1,2-c][1,3]benzodiazepine.

Workup

  1. temperatureis refluxed under nitrogen for 48 hours
  2. filtrationfiltered
  3. customThe filtrates are evaporated to dryness
  4. customthe product is purified

Sources & evidence

ORD record
ord-e0e50fecc9b24b8bb5015dcd34c54765
Source dataset
uspto-grants-1984_07
Patent number
US04460587

Reaction notes

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