1,1'-Carbonyldiimidazole → HCID 13474164, compound

HRID 1462452Notes

Reaction equation

HRID 1462452 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH2:14])[NH:5][CH:6]=1.[C:15](N1C=CN=C1)(N1C=CN=C1)=[O:16]>C(Cl)Cl>[CH3:1][C:2]1[N:3]=[C:4]2[CH2:7][C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[NH:14][C:15](=[O:16])[N:5]2[CH:6]=1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 178430865HCID 178430865, compound

Product 1

HCID 13474164HCID 13474164, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 18.61 g of 4-methyl-2-(2-aminobenzyl)imidazole, 16.12 g of 1,1'-carbonyldiimidazole and 375 ml of methylene chloride is stirred at room temperature overnight. The methylene chloride is evaporated to a small volume, the mixture is cooled to 0° and the solids are filtered and washed with ether to give 2-methyl-11H-imidazo[1,2-c][1,3]benzodiazepine-5(6H)-one, m.p. 234.5°-236.5°.

Workup

  1. customThe methylene chloride is evaporated to a small volume
  2. temperaturethe mixture is cooled to 0°
  3. filtrationthe solids are filtered
  4. washwashed with ether

Sources & evidence

ORD record
ord-5e03093a1ee740b5872a99d5f3f479ae
Source dataset
uspto-grants-1984_07
Patent number
US04460587

Reaction notes

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