Ethoxy(4-phenylbutyl)phosphinyl chloride → HCID 86739549, compound

HRID 1462484Notes

Reaction equation

HRID 1462484 reaction equation
Cl[P:2]([CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:6])[O:3][CH2:4][CH3:5].[NH2:17][CH:18]1[CH2:24][CH2:23][S:22][CH2:21][N:20]([CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[C:19]1=[O:31]>C(Cl)Cl>[CH2:4]([O:3][P:2]([NH:17][CH:18]1[CH2:24][CH2:23][S:22][CH2:21][N:20]([CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[C:19]1=[O:31])([CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:6])[CH3:5]

Participants

4

Reactant 2

HCID 15591238Ethoxy(4-phenylbutyl)phosphinyl chlorideHCID 86739550HCID 86739550, compound

Product 1

HCID 86739549HCID 86739549, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of crude chloro(4-phenylbutyl)phosphinic acid, ethyl ester, dry methylene chloride and 5-amino-tetrahydro-4-oxo-1,3-thiazepine-3(2H)-acetic acid, ethyl ester are reacted as set forth in Example 1(f). Work up of the reaction mixture according to Example 1(f) yields 5-[[ethoxy(4-phenylbutyl)phosphinyl]amino]tetrahydro-4-oxo-1,3-thiazepine-3(2H)-acetic acid, ethyl ester.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-7d1c0677baf34c3da179bbb442f969e5
Source dataset
uspto-grants-1984_07
Patent number
US04460579

Reaction notes

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