反应详情

温度

80 °C

1.9 Grams of 6-{1-hydroxy-4-[4-(3-chlorophenyl) -1- piperazinyl]butyl}-3,4-dihydrocarbostyril was dissolved in 50 ml of acetic acid and further 2 ml of concentrated hydrochloric acid was added to this solution. The solution was stirred at 80° C. for 30 minutes and the reaction mixture was concentrated under a reduced pressure to dryness to obtain a residue. To the residue was added 10N-NaOH and ether and stirred at a room temperature for 30 minutes. The crystals thus precipitated were collected by filtration and separated by a silica-gel chromatography. Recrystallized from ethanol-chloroform to obtain 6-{4-[4-(3-chlorophenyl)-1-piperazinyl]-1- butenyl}-3,4-dihydrocarbostyril in colorless prism-like crystals. Yield: 1.6 g. Melting point: 175° -176° C.

1. concentrationthe reaction mixture was concentrated under a reduced pressure to dryness
2. customto obtain a residue
3. stirringstirred at a room temperature for 30 minutes
4. customThe crystals thus precipitated
5. filtrationwere collected by filtration
6. customseparated by a silica-gel chromatography
7. customRecrystallized from ethanol-chloroform