Hydrochloric Acid → HCID 70456409, compound

HRID 1462928Notes

Reaction equation

HRID 1462928 reaction equation
[OH-].[Na+].[NH:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][C:9]1[CH:21]=[CH:20][C:12]([O:13][CH2:14][C:15]([O:17]CC)=[O:16])=[CH:11][CH:10]=1.[ClH:22]>O>[OH2:13].[ClH:22].[NH:3]1[CH:7]=[CH:6][N:5]=[C:4]1[CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH2:14][C:15]([OH:17])=[O:16])=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70456159HCID 70456159, compound

Product 1

HCID 70456409HCID 70456409, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 0.42 g of sodium hydroxide in 30 ml of water was added 2.3 g of ethyl 4-(1-imidazolylmethyl)phenoxyacetate and the mixture was stirred at room temperature for 20 minutes. After completion of the reaction, an adequate amount of diluted hydrochloric acid was added to the solution to make it acidic. The reaction mixture was concentrated to dryness under reduced pressure, and the residue was recrystallized from water to obtain 2.4 g of 4-(1-imidazolylmethyl)phenoxyacetic acid hydrochloride monohydrate (94.9% yield). Colorless needles.

Workup

  1. customAfter completion of the reaction
  2. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
  3. customthe residue was recrystallized from water

Sources & evidence

ORD record
ord-df4a042d9fbf47e1abbd2ae30cb0dedf
Source dataset
uspto-grants-1984_07
Patent number
US04461905

Reaction notes

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