HCID 20452407, compound → 2-Pyrrolidinone, 1-(3-hydroxy-4-methoxybenzoyl)-

HRID 1462944Notes

Reaction equation

HRID 1462944 reaction equation
C([O:9][C:10]1[CH:11]=[C:12]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[C:13]([N:15]1[CH2:19][CH2:18][CH2:17][C:16]1=[O:20])=[O:14])(=O)C1C=CC=CC=1>C(OCC)(=O)C.[H][H].[Pd]>[OH:9][C:10]1[CH:11]=[C:12]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[C:13]([N:15]1[CH2:19][CH2:18][CH2:17][C:16]1=[O:20])=[O:14]

Participants

5

Reactant 1

HCID 20452407HCID 20452407, compound

Product 1

HCID 30608052-Pyrrolidinone, 1-(3-hydroxy-4-methoxybenzoyl)-

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

150 mg of 1-(3-benzoyloxy-4-methoxybenzoyl)pyrrolin-2-one are dissolved in 100 ml of ethyl acetate and hydrogenated with hydrogen over 150 mg of 5% palladium/carbon at atmospheric pressure. The catalyst is filtered off and the filtrate is concentrated. The residue is stirred at room temperature in diethyl ether. After filtration, there is obtained 1-(3-hydroxy-4-methoxybenzoyl)-2-pyrrolidinone of melting point 122°-124° C.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. filtrationAfter filtration

Sources & evidence

ORD record
ord-7f1a944a48a64e1d82caf617387b18ba
Source dataset
uspto-grants-1984_07
Patent number
US04461906

Reaction notes

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