Potassium Acetate → HCID 178447934, compound

Participants

Reaction Steps

31.1 g of ethyl trans-4-chloro-2-(4-propylcyclohexyl)-5-pyrimidinecarboxylate are dissolved in 350 ml of ethanol and, after adding 14.1 g of potassium acetate and 2.56 g of palladium/carbon (5% by weight), the mixture is hydrogenated at room temperature until 0.10-0.11 mol of hydrogen have been taken up. The mixture is suction filtered, back-washed with methylene chloride and evaporated in vacuo. Thereby, there are obtained 35.6 g of crude, partly crystalline ethyl trans-2-(4-propylcyclohexyl)-5-pyrimidinecarboxylate which is used in the next step without further purification.

Provenance & Evidence