Potassium Acetate → HCID 178447934, compound

HRID 1463009Notes

Reaction equation

HRID 1463009 reaction equation
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14]2)[N:3]=1.C([O-])(=O)C.[K+].[H][H]>C(O)C.[Pd]>[CH2:19]([C@H:16]1[CH2:15][CH2:14][C@H:13]([C:4]2[N:3]=[CH:2][C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=2)[CH2:18][CH2:17]1)[CH2:20][CH3:21]

Participants

6

Reactant 3

HCID 517044Potassium AcetateHCID 178418361HCID 178418361, compoundHCID 178447933HCID 178447933, compound

Product 1

HCID 178447934HCID 178447934, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

31.1 g of ethyl trans-4-chloro-2-(4-propylcyclohexyl)-5-pyrimidinecarboxylate are dissolved in 350 ml of ethanol and, after adding 14.1 g of potassium acetate and 2.56 g of palladium/carbon (5% by weight), the mixture is hydrogenated at room temperature until 0.10-0.11 mol of hydrogen have been taken up. The mixture is suction filtered, back-washed with methylene chloride and evaporated in vacuo. Thereby, there are obtained 35.6 g of crude, partly crystalline ethyl trans-2-(4-propylcyclohexyl)-5-pyrimidinecarboxylate which is used in the next step without further purification.

Workup

  1. filtrationfiltered
  2. washback-washed with methylene chloride
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-356a035b3c834b14859c3694c2198fa7
Source dataset
uspto-grants-1984_07
Patent number
US04462923

Reaction notes

Loading…