Ethyl alpha-oxobenzenebutanoate → HCID 13295431, compound

HRID 1463030Notes

Reaction equation

HRID 1463030 reaction equation
Cl.[NH2:2][C@H:3]([C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])[CH3:4].[O-]CC.[Na+].C(O)C.O=[C:20]([CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:21]([O:23][CH2:24][CH3:25])=[O:22].C([BH3-])#N.[Na+]>CCOCC.C(O)C>[CH2:24]([O:23][C:21]([C@@H:20]([NH:2][C@H:3]([C:5]([O:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6])[CH3:4])[CH2:26][CH2:27][C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)=[O:22])[CH3:25]

Participants

7

Reactant 4

HCID 562087Ethyl alpha-oxobenzenebutanoateHCID 5003444Sodium cyanoborohydrideHCID 11275390tert-Butyl alaninate hydrochlorideHCID 23706232Ethanol sodium ethoxide2×

Product 1

HCID 13295431HCID 13295431, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent3×HCID 3283Diethyl EtherSolvent

Procedure

To a solution of L-alanine, t-butyl ester, hydrochloride (4.86 g., 26.7 mmole) in 35 ml. of absolute ethanol, there is added 4.2 ml. (6.72 mmole) of 1.6 N sodium ethoxide/ethanol. To the resulting milky solution which is approximately pH 7.5, is added a solution of ethyl 2-oxo-4-phenylbutyrate [prepared by treating ethyl 2-hydroxy-4-phenylbutyrate with oxalyl chloride] (27.6 g.,0.135 mmole) in 25 ml. of ethanol followed by 22 g. of powdered 3A° molecular sieves. The resulting mixture is stirred at room temperature and during the next 30 minutes a total of 4.8 ml. (7.68 mmole) of 1.6 N sodium ethoxide/ethanol is added to maintain a pH of between 6 and 7. After stirring for an additional 30 minutes, a solution of sodium cyanoborohydride (3.35 g., 53.5 mmole) in 20 ml. of ethanol is added over a period of six hours. After stirring for 40 hours, the mixture is filtered through celite and then evaporated at reduced pressure. The residue is dissolved in 350 ml. of ether and the resulting solution is washed with water (3×100 ml.) and then extracted with 1N hydrochloric acid (3×100 ml.). The hydrochloric acid extracts are combined and washed with ether and basified with 4N sodium hydroxide (70 ml.) followed by 1N sodium bicarbonate. The resulting mixture is extracted with ether (2×350 ml.). The ether fractions are combined, washed with water and brine, and dried (MgSO4). The solvent is removed at reduced pressure to give crude product as a mixture of diastereomers Rf =0.46 (undesired isomer) and 0.36 (desired isomer), silica gel, petroleum ether: ether, 1:1). The crude material is then filtered through a column of silica gel (petroleum ether:ether, 3:1). Chromatography (silica gel, hexane:ethyl acetate, 92:8) yields N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine, t-butyl ester as a colorless oil. Rf =0.36 (silica gel, petroleum ether:ether, 1:1).

Workup

  1. temperatureto maintain a pH of between 6 and 7
  2. stirringAfter stirring for an additional 30 minutes
  3. stirringAfter stirring for 40 hours
  4. filtrationthe mixture is filtered through celite
  5. customevaporated at reduced pressure
  6. dissolutionThe residue is dissolved in 350 ml
  7. washof ether and the resulting solution is washed with water (3×100 ml.)
  8. extractionextracted with 1N hydrochloric acid (3×100 ml.)
  9. washwashed with ether
  10. extractionThe resulting mixture is extracted with ether (2×350 ml.)
  11. washwashed with water and brine
  12. dry with materialdried (MgSO4)
  13. customThe solvent is removed at reduced pressure
  14. customto give crude product
  15. filtrationThe crude material is then filtered through a column of silica gel (petroleum ether:ether, 3:1)

Sources & evidence

ORD record
ord-e7aca8b517624c7496143c009b9a1b5a
Source dataset
uspto-grants-1984_07
Patent number
US04462943

Reaction notes

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