Sodium Iodide → HCID 131713608, compound

HRID 1463047Notes

Reaction equation

HRID 1463047 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:23][O:24][CH3:25])[C:8]([NH:10][CH:11]2[C:21](=[O:22])[N:13]3[C:14]([C:18]([O-:20])=[O:19])=[CH:15][CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1.[Na+].[C:27]([O:30][CH:31](Br)[CH2:32][CH2:33][CH3:34])(=[O:29])[CH3:28].[I-].[Na+]>>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:23][O:24][CH3:25])[C:8]([NH:10][CH:11]2[C:21](=[O:22])[N:13]3[C:14]([C:18]([O:20][CH:31]([O:30][C:27](=[O:29])[CH3:28])[CH2:32][CH2:33][CH3:34])=[O:19])=[CH:15][CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 23362791HCID 23362791, compoundHCID 131712445Sodium 7-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate

Product 1

HCID 131713608HCID 131713608, compound

Procedure

In the same manner as Example 1, sodium 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn-isomer) was reacted with 1-bromobutyl acetate in the presence of sodium iodide to give 1-acetoxybutyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn-isomer), mp 100°-105° C. (decompn.).

Sources & evidence

ORD record
ord-82cb4062e070461ebffd0acc980ea43b
Source dataset
uspto-grants-1984_07
Patent number
US04463002

Reaction notes

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