Hydrazine hydrate (1:1) → HCID 13191620, compound

HRID 1463053Notes

Reaction equation

HRID 1463053 reaction equation
O.[NH2:2][NH2:3].[Cl:4][C:5]1[N:14]=[C:13](Cl)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1>C(Cl)Cl>[Cl:4][C:5]1[N:14]=[C:13]([NH:2][NH2:3])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2528862,4-Dichloroquinazoline

Product 1

HCID 13191620HCID 13191620, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

87 g (1.74 moles) of hydrazine hydrate were added dropwise to a suspension of 86.5 g (0.43 mole) of 2,4-dichloroquinazoline in 1500 ml of methylene chloride at room temperature, while cooling with ice and stirring vigorously. After 8 hours at room temperature, the precipitate was filtered off under suction, washed with water and dried. Yield: 78.4 g (92%) of 2-chloro-4-hydrazinoquinazoline, mp.>280° C.

Workup

  1. temperaturewhile cooling with ice
  2. filtrationthe precipitate was filtered off under suction
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-38c2ecbb40774c92b0f25926bba17140
Source dataset
uspto-grants-1984_07
Patent number
US04463007

Reaction notes

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