反应详情

A mixture of thiocytosine (0.7 g.), sodium hydroxide(0.22 g.) and 4-(3-chloropropyl)imidazole (0.8 g.) was stirred in EtOH (8 ml.) and water (8 ml.) at room temperature for 16 hours and then heated under reflux for 2 hours. The solution was evaporated to dryness and the residue partitioned between dilute aqueous sodium hydroxide (20 ml.) and EtOAc (30 ml.). The EtOAc layer was evaporated to dryness to give 4-[3-(4-aminopyrimid-2-ylthio)propyl]imidazole as a brown gum which was used without further purification.

1. temperatureheated
2. temperatureunder reflux for 2 hours
3. customThe solution was evaporated to dryness
4. customthe residue partitioned between dilute aqueous sodium hydroxide (20 ml.) and EtOAc (30 ml.)
5. customThe EtOAc layer was evaporated to dryness