Water → HCID 178507908, Verbindung

HRID 1463060Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1463060
[NH:1]1[CH:8]=[CH:7][C:5]([NH2:6])=[N:4][C:2]1=[S:3].[OH-].[Na+].Cl[CH2:12][CH2:13][CH2:14][C:15]1[N:16]=[CH:17][NH:18][CH:19]=1.O>CCO>[NH2:6][C:5]1[CH:7]=[CH:8][N:1]=[C:2]([S:3][CH2:12][CH2:13][CH2:14][C:15]2[N:16]=[CH:17][NH:18][CH:19]=2)[N:4]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 178478458HCID 178478458, VerbindungHCID 178507915HCID 178507915, Verbindung

Produkt 1

HCID 178507908HCID 178507908, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of thiocytosine (0.7 g.), sodium hydroxide(0.22 g.) and 4-(3-chloropropyl)imidazole (0.8 g.) was stirred in EtOH (8 ml.) and water (8 ml.) at room temperature for 16 hours and then heated under reflux for 2 hours. The solution was evaporated to dryness and the residue partitioned between dilute aqueous sodium hydroxide (20 ml.) and EtOAc (30 ml.). The EtOAc layer was evaporated to dryness to give 4-[3-(4-aminopyrimid-2-ylthio)propyl]imidazole as a brown gum which was used without further purification.

Aufarbeitung

  1. temperatureheated
  2. temperatureunder reflux for 2 hours
  3. customThe solution was evaporated to dryness
  4. customthe residue partitioned between dilute aqueous sodium hydroxide (20 ml.) and EtOAc (30 ml.)
  5. customThe EtOAc layer was evaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-f2b320253dad4fc79b9a71707662fa09
Quelldatensatz
uspto-grants-1984_07
Patentnummer
US04463005

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