Trityl chloride → 2-Fluoro-1-trityl-1H-imidazole

Reaktionsgleichung

[F:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[C:7]1([C:13](Cl)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(Cl)Cl.CN(C)C>[F:1][C:2]1[N:3]([C:13]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:4]=[CH:5][N:6]=1

Komponenten

Versuchsvorschrift

To a solution of 2-fluoroimidazole (4.45 g.) in CH2Cl2 (100 ml.) and trimethylamine (7.93 ml.) was added triphenylmethyl chloride (14.4 g.) and the mixture was stirred for 2.5 hours. The solution was washed with water and brine, dried (MgSO4), treated with decolourising charcoal, filtered and evaporated. The solid residue was triturated with ether followed by methanol to give 2-fluoro-1-triphenylmethylimidazole (13.6 g.), m.p. 182°-185°.