Trityl chloride → 2-Fluoro-1-trityl-1H-imidazole

HRID 1463163노트

반응식

HRID 1463163 반응식
[F:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[C:7]1([C:13](Cl)([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(Cl)Cl.CN(C)C>[F:1][C:2]1[N:3]([C:13]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)([C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:4]=[CH:5][N:6]=1

참가 물질

5

반응물 2

HCID 6456Trityl chlorideHCID 5595422-Fluoro-1H-imidazole

생성물 1

HCID 204324542-Fluoro-1-trityl-1H-imidazole수율 80.2%

시약·촉매·용매 2

HCID 1146Trimethylamine용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-fluoroimidazole (4.45 g.) in CH2Cl2 (100 ml.) and trimethylamine (7.93 ml.) was added triphenylmethyl chloride (14.4 g.) and the mixture was stirred for 2.5 hours. The solution was washed with water and brine, dried (MgSO4), treated with decolourising charcoal, filtered and evaporated. The solid residue was triturated with ether followed by methanol to give 2-fluoro-1-triphenylmethylimidazole (13.6 g.), m.p. 182°-185°.

후처리

  1. washThe solution was washed with water and brine
  2. dry with materialdried (MgSO4)
  3. additiontreated with decolourising charcoal
  4. filtrationfiltered
  5. customevaporated
  6. customThe solid residue was triturated with ether

출처 및 근거

ORD 기록
ord-e7c379ff1f7149e8bbe262c56dbec46d
출처 데이터셋
uspto-grants-1984_07
특허 번호
US04463173

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