Triethylamine → HCID 20451930, compound

HRID 1463171Notes

Reaction equation

HRID 1463171 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][OH:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>C(Cl)Cl>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:11][O:12][S:29]([CH3:28])(=[O:31])=[O:30])=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 12985259HCID 12985259, compound

Product 1

HCID 20451930HCID 20451930, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1,2-di(t-butoxycarbonylamino)-3-hydroxypropane (3 g.) and triethylamine (2 ml.) in CH2Cl2 (30 ml.) at 0° was added methanesulphonyl chloride (1.0 ml.) with stirring. Stirring at this temperature was continued for 1 hour and the mixture was then washed with water. The organic layer was separated, dried and the solvent evaporated to give 1,2-di(t-butoxycarbonylamino)-3-methanesulphonyloxypropane (2.9 g.), m.p. 94°-96°.

Workup

  1. stirringStirring at this temperature
  2. washthe mixture was then washed with water
  3. customThe organic layer was separated
  4. customdried
  5. customthe solvent evaporated

Sources & evidence

ORD record
ord-d83812bb56a44acb9a0a742d4404a8ff
Source dataset
uspto-grants-1984_07
Patent number
US04463173

Reaction notes

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