Acetohydrazide → 2-Fluoro-6-(4-methyl-1-piperazinyl)pyridine-3-carboxaldehyde acetylhydrazone

HRID 1463225Notes

Reaction equation

HRID 1463225 reaction equation
[F:1][C:2]1[C:7]([CH:8]=O)=[CH:6][CH:5]=[C:4]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)[N:3]=1.[C:17]([NH:20][NH2:21])(=[O:19])[CH3:18]>CCO>[C:17]([NH:20][N:21]=[CH:8][C:7]1[C:2]([F:1])=[N:3][C:4]([N:10]2[CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]2)=[CH:5][CH:6]=1)(=[O:19])[CH3:18]

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 106328592-Fluoro-6-(4-methyl-1-piperazinyl)pyridine-3-carboxaldehyde

Product 1

HCID 541133102-Fluoro-6-(4-methyl-1-piperazinyl)pyridine-3-carboxaldehyde acetylhydrazone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Fluoro-6-(4-methyl-1-piperazinyl)pyridine-3-carboxaldehyde (3.35 g, 0.015 mole) was dissolved in 20 mL of EtOH and treated with acetylhydrazine (2.2 g, 0.030 mole). This reaction mixture was stirred for 72 hours and then the product was filtered off and recrystallized from EtOAc to give 2.85 g, mp 210°-212° C.

Workup

  1. filtrationthe product was filtered off
  2. customrecrystallized from EtOAc
  3. customto give 2.85 g, mp 210°-212° C.

Sources & evidence

ORD record
ord-3d9466cf7d4e46898deb660729bc7032
Source dataset
uspto-grants-1994_04
Patent number
US05300498

Reaction notes

Loading…