反应详情

30 mg (0.1 mmol) of 5-(4-hydroxymethylbenzoyl)-3-thiophene sulfonamide and 300 mg of MnO2 were added to 5 mL of THF. After stirring at rt for 30 min the mixture was filtered through a bed of celite and eluted with ethyl acetate. The filtrate was concentrated and the crude product subjected to flash chromatography utilizing 1:1 ethyl acetate/hexane as the eluent to recover 16 mg of 5-(4-formylbenzoyl)-3-thiophene sulfonamide as a yellow solid.

1. filtrationwas filtered through a bed of celite
2. washeluted with ethyl acetate
3. concentrationThe filtrate was concentrated
4. customto recover 16 mg of 5-(4-formylbenzoyl)-3-thiophene sulfonamide as a yellow solid