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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1463354생성일: 2026년 10월 25일

Ethanesulfonyl chloride → [(Ethylsulfonyl)amino[methyl]-1H-indol-3-yl]propyl-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine

https://huagongshe.com/reaction/1463354

반응식

참여 물질

역할이름HCID투입량
반응물Ethanesulfonyl chlorideHCID 11667—
반응물1-(5-Methoxy-4-pyrimidinyl)-2-methylpiperazineHCID 19081474—
반응물1-[[5-[[(ethylsulfonyl)amino]methyl]-1H-indol-3-yl]propyl]-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazineHCID 54519656—
생성물[(Ethylsulfonyl)amino[methyl]-1H-indol-3-yl]propyl-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazineHCID 86747728—

반응 단계

In a similar manner to Example 32 1-[[5-[[(ethylsulfonyl)amino]methyl]-1H-indol-3-yl]propyl]-4-(5-methoxy-4-pyrimidinyl)-3-methylpiperazine was synthesized by utilizing 1-(5-methoxy-4-pyrimidinyl)-2-methylpiperazine in the coupling step and ethanesulfonyl chloride in the sulfonylation step: C24H34N6O3S/2.9 HCl, m.p. 202°-210° C. Elemental analysis calculated: C, 48.66; H, 6.28; N, 14.19; found: C, 48.41; H, 6.35; N, 13.93.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US05300506
출처 데이터셋uspto-grants-1994_04
ORD IDord-f45445771a204e65b92a639b93e00413
출처 메모uspto-grants-1994_04