Hydrochloric Acid → HCID 19090371, compound

HRID 1463475Notes

Reaction equation

HRID 1463475 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][C:11]3[NH:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]=3[N:18]=2)=[CH:5][CH:4]=1)#[N:2].[ClH:19].[CH2:20]([OH:22])[CH3:21]>>[ClH:19].[ClH:19].[CH2:20]([O:22][C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:10][C:11]3[NH:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]=3[N:18]=2)=[CH:7][CH:8]=1)=[NH:2])[CH3:21]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 10060927HCID 10060927, compound

Product 1

HCID 19090371HCID 19090371, compound

Procedure

A solution (700 ml) of 2-(4-cyanophenyl)-5,6,7,8-tetrahydro-4H-thiazolo[5,4-b]azepine (8.00 g) in ethanol was saturated with hydrogen chloride, and allowed to stand overnight. It was concentrated under reduced pressure, and the residue was washed with ethyl ether and dried to give the title compound as a powder.

Workup

  1. concentrationIt was concentrated under reduced pressure
  2. washthe residue was washed with ethyl ether
  3. customdried

Sources & evidence

ORD record
ord-b92170a5998546be9fe391cf0b959b08
Source dataset
uspto-grants-1994_04
Patent number
US05300639

Reaction notes

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