Sodium Bicarbonate → HCID 19090372, compound

HRID 1463476Notes

Reaction equation

HRID 1463476 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[S:15][C:16]3[NH:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]=3[N:23]=2)=[CH:10][CH:9]=1)=[NH:7])[CH3:4].C(=O)([O-])O.[Na+]>>[CH2:3]([O:5][C:6]([C:8]1[CH:9]=[CH:10][C:11]([C:14]2[S:15][C:16]3[NH:17][CH2:18][CH2:19][CH2:20][CH2:21][C:22]=3[N:23]=2)=[CH:12][CH:13]=1)=[NH:7])[CH3:4]

Participants

3

Reactant 2

HCID 516892Sodium BicarbonateHCID 19090371HCID 19090371, compound

Product 1

HCID 19090372HCID 19090372, compoundYield 91.1%

Procedure

2-(4-Ethoxyformimidoylphenyl)-5,6,7,8-tetrahydro-4H-thiazolo[5,4-b]azepine dihydrochloride (1.5 g) was neutralized with an aqueous sodium hydrogen carbonate, and extracted with chloroform. The extract was washed with water, dried and distilled under reduced pressure to remove the solvent. The residue was purified by a column chromatography on silica gel to give the title compound as a powder (yield 1.1 g, 87%).

Workup

  1. extractionextracted with chloroform
  2. washThe extract was washed with water
  3. customdried
  4. distillationdistilled under reduced pressure
  5. customto remove the solvent
  6. customThe residue was purified by a column chromatography on silica gel

Sources & evidence

ORD record
ord-80dc9410a3dd497a9e0931d16c486ab5
Source dataset
uspto-grants-1994_04
Patent number
US05300639

Reaction notes

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