反应详情

Diethyl 3-trifluoromethylbenzylphosphonate (3.0 g, 10.0 mmol) was dissolved in a mixture of 50 mL of conc hydrochloric acid and 1.5 mL of EtOH and was heated at reflux for 17 hours. After cooling the clear reaction mixture in an ice-water mixture, the white crystalline solid which formed was collected to give 2.05 g (84.3%) of the analytical product, mp=163°-164° C.; D.C.I.M.S.[MH+,241].

1. temperaturewas heated
2. temperatureat reflux for 17 hours
3. customthe white crystalline solid which formed
4. customwas collected