Ethyl 3-aminopropyl(phenyl)phosphinate → 3-Aminopropyl(phenyl)phosphinic acid

HRID 1463599Notes

Reaction equation

HRID 1463599 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:9])[O:6]CC>Cl>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(=[O:6])[OH:9]

Participants

3

Reactant 1

HCID 19090874Ethyl 3-aminopropyl(phenyl)phosphinate

Product 1

HCID 101042063-Aminopropyl(phenyl)phosphinic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 6.83 g of ethyl 3-aminopropyl(phenyl)phosphinate and 30 ml of 20% hydrochloric acid is refluxed with stirring for 4 hours. The clear solution is evaporated to dryness and the residue is recrystallized from methanol/propylenoxide to give 3-aminopropyl(phenyl)phosphinic acid as a white solid, m.p. 298°-300°.

Workup

  1. temperatureis refluxed
  2. customThe clear solution is evaporated to dryness
  3. customthe residue is recrystallized from methanol/propylenoxide

Sources & evidence

ORD record
ord-50d1ba61d05c413d8eff5ddee7e9db50
Source dataset
uspto-grants-1994_04
Patent number
US05300679

Reaction notes

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