HCID 19090869, compound → HCID 19090888, compound

HRID 1463641Notes

Reaction equation

HRID 1463641 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:20]([PH:24](=[O:28])[O:25][CH2:26][CH3:27])[CH2:21][CH2:22][CH3:23]>C(N(CC)CC)C>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=1)[CH:11]([P:24]([CH2:20][CH2:21][CH2:22][CH3:23])(=[O:28])[O:25][CH2:26][CH3:27])[OH:12])=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 19090869HCID 19090869, compoundHCID 178454912HCID 178454912, compound

Product 1

HCID 19090888HCID 19090888, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A material of 283 mg of 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-propionaldehyde, 150 mg of ethyl n-butyl-phosphinate and 101 mg of triethylamine is heated to 100° C. for 21/2 hours. The mixture is cooled to room temperature and the volatile components are removed in high vacuum. Chromatography of the residue on silica-gel affords ethyl 3-(N-tert.-butyloxycarbonylamino)-2-(4-chlorophenyl)-1-hydroxy-propyl-(n-butyl)phosphinate.

Workup

  1. customthe volatile components are removed in high vacuum

Sources & evidence

ORD record
ord-b205dd544fd1470987a7b3adc54e4d6b
Source dataset
uspto-grants-1994_04
Patent number
US05300679

Reaction notes

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