Dichloromethane → HCID 67749684, compound

HRID 1463727Notes

Reaction equation

HRID 1463727 reaction equation
[O-2].[Ca+2:2].[CH2:3]([C:9](=[CH:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH:10]([OH:17])[C:11]([CH3:16])([CH3:15])[C:12]([OH:14])=[O:13])[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].ClCCl>O>[OH:17][CH:10]([C:9](=[CH:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[C:11]([CH3:15])([CH3:16])[C:12]([O-:14])=[O:13].[OH:17][CH:10]([C:9](=[CH:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[C:11]([CH3:15])([CH3:16])[C:12]([O-:14])=[O:13].[Ca+2:2]

Participants

5

Reactant 3

HCID 6344Dichloromethane2×HCID 6850728CalciumoxideHCID 53990596HCID 53990596, compound

Product 1

HCID 67749684HCID 67749684, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 1 g (0.018 mole) quantity of calcium oxide was suspended in 100 mL of distilled water, and 4 g (0.013 mole) of 4-hexyl-3-hydroxy-2,2-dimethyl-5-phenyl-4-pentenoic acid was added to the suspension. After stirring for 4 days at room temperature, 50 mL of dichloromethane was added to the suspension and the mixture was stirred vigorously for 30 minutes. Another 50 mL of dichloromethane was added and the aqueous layer was separated. The aqueous phase was washed with 50 mL of dichloromethane, and the combined organic phase was evaporated to dryness to provide 4.8 g of crude product.

Workup

  1. stirringthe mixture was stirred vigorously for 30 minutes
  2. customthe aqueous layer was separated
  3. washThe aqueous phase was washed with 50 mL of dichloromethane
  4. customthe combined organic phase was evaporated to dryness

Sources & evidence

ORD record
ord-2c5e36d94b394ecdb31e56420b214858
Source dataset
uspto-grants-1994_04
Patent number
US05301693

Reaction notes

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