反应详情

A solution of (S)-1-O-benzyl-2-O-[(diisopropylphosphono)methyl]-1,2-propanediol (8.20 g, 23.8 mmol) in 1:1 ethanol/cyclohexene (80 mL) was treated with 20% palladium hydroxide on carbon (4.0 g), and the mixture was heated at reflux for 18 hours. The reaction mixture was then filtered through a 1" pad of Celite, and the filtrate was concentrated in vacuo to give 6.3 g of the title compound as a clear, colorless oil which was used in the following reaction without purification.

1. temperaturethe mixture was heated
2. temperatureat reflux for 18 hours
3. filtrationThe reaction mixture was then filtered through a 1" pad of Celite
4. concentrationthe filtrate was concentrated in vacuo