Hydrazine → 3-(1-Methylpiperazin-2-YL)propan-1-amine

HRID 1463815Notes

Reaction equation

HRID 1463815 reaction equation
[NH2:1]N.[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12]C1C=CC=C2C(NC(=O)C=12)=O>CO>[CH3:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH:5]1[CH2:10][CH2:11][CH2:12][NH2:1]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 537877233-(N-methylpiperazinyl)propylphthalimide

Product 1

HCID 450994643-(1-Methylpiperazin-2-YL)propan-1-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrazine (aqueous solution at 35% by wt.) (0.15 ml; 1.6 mmoles) was added to 3-(N-methylpiperazinyl)propylphthalimide (229 mg; 0.8 mmoles) in methanol (5 ml) and the resulting solution was refluxed. Reaction times and process as per Example 1.

Workup

  1. temperaturethe resulting solution was refluxed
  2. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-4c3444155e9d48f29cbdb83b19d8f482
Source dataset
uspto-grants-1994_04
Patent number
US05302593

Reaction notes

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