Diethyl Ether → 8-Piperidinyloctylphthalimide

HRID 1463823Notes

Reaction equation

HRID 1463823 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]1[CH:20]=[CH:19][CH:18]=[C:12]2[C:13]([NH:15][C:16](=[O:17])[C:11]=12)=[O:14].N1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.[CH2:27](OCC)C>>[N:24]1([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]2[CH:20]=[CH:19][CH:18]=[C:12]3[C:13]([NH:15][C:16](=[O:17])[C:11]=23)=[O:14])[CH2:25][CH2:26][CH2:27][CH2:22][CH2:23]1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 4837PiperazineHCID 232906438-Bromooctylphthalimide

Product 1

HCID 540305088-Piperidinyloctylphthalimide

Procedure

8Bromooctylphthalimide (517 mg; 2.0 mmoles) and piperazine (0.40 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). Reaction times and process as per Example 1.

Workup

  1. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-c603ca587ae64992a44adedbd7ab89d9
Source dataset
uspto-grants-1994_04
Patent number
US05302593

Reaction notes

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