HCID 19088483, compound → 2,2-Diphenyl-5-methylaminopentanamide

HRID 1463874Notes

Reaction equation

HRID 1463874 reaction equation
[CH2:1]([N:8]([CH2:10][CH2:11][CH2:12][C:13]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:14]([NH2:16])=[O:15])C)C1C=CC=CC=1>C(O)C.[Pd]>[C:17]1([C:13]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([CH2:12][CH2:11][CH2:10][NH:8][CH3:1])[C:14]([NH2:16])=[O:15])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 1

HCID 19088483HCID 19088483, compound

Product 1

HCID 190884752,2-Diphenyl-5-methylaminopentanamide

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 5-(N-benzyl-N-methylamino)-2,2-diphenylpentanamide (11 g--see Example 1) and 10% palladium-on-carbon (1.1 g) in ethanol (150 ml) was hydrogenated at room temperature and 50 p.s.i. (344.7 kPa) pressure for 87 hours. The mixture was filtered and the filtrate concentrated in vacuo to give an oil. The oil was triturated with ether to give the title compound as a colourless powder, yield 4.5 g.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate concentrated in vacuo
  4. customto give an oil
  5. customThe oil was triturated with ether

Sources & evidence

ORD record
ord-a553a0d9a21c45668aa8847cb0a8e669
Source dataset
uspto-grants-1994_04
Patent number
US05302595

Reaction notes

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