HCID 19088503, compound → HCID 19088472, compound

HRID 1463880Notes

Reaction equation

HRID 1463880 reaction equation
[CH2:1]([N:8]([C:10]([CH3:30])([CH3:29])[CH2:11][CH2:12][C:13]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:14]([NH2:16])=[O:15])C)C1C=CC=CC=1>CO.C(O)=O.[Pd]>[C:17]1([C:13]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([CH2:12][CH2:11][C:10]([CH3:30])([NH:8][CH3:1])[CH3:29])[C:14]([NH2:16])=[O:15])[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 1

HCID 19088503HCID 19088503, compound

Product 1

HCID 19088472HCID 19088472, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 284Formic AcidSolventHCID 887MethanolSolvent

Procedure

10% Palladium-on-carbon was added to a solution of 5-(N-benzyl-N-methylamino)-2,2-diphenyl-5-methylhexanamide (0.6 g--see Example 3) in methanol (19 ml) and formic acid (1 ml). The mixture was stirred at room temperature for 16 hours then filtered and the filtrate concentrated in vacuo to give the title compound as a gum, yield 0.4 g.

Workup

  1. filtrationthen filtered
  2. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-35576e9b257341f38d14e42aec801a9c
Source dataset
uspto-grants-1994_04
Patent number
US05302595

Reaction notes

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