Water → 2-(2,3-Dihydro-1-benzofuran-5-yl)ethan-1-ol

A solution of (2,3-dihydrobenzofuran-5-yl)acetic acid (4.9 g--see EP-A-132130) in anhydrous tetrahydrofuran (50 ml) was added over 10 minutes, dropwise, to a stirred suspension of lithium aluminum hydride (1.57 g) in anhydrous tetrahydrofuran (50 ml) at 0°. The mixture was allowed to warm to room temperature and stirred for 1 hour. Water (1.5 ml) was then added dropwise with caution followed by 10% aqueous sodium hydroxide (1.5 ml) and, finally, water (4.5 ml). The mixture was filtered and the inorganic salts washed with ethyl acetate (2×50 ml). The filtrate and washings were combined and concentrateed in vacuo to give the title compound as an oil, yield 3.3 g.

1. filtrationThe mixture was filtered
2. washthe inorganic salts washed with ethyl acetate (2×50 ml)

ORD record

ord-ad4218bce4aa48d9981bf14b9e7a2f78

Source dataset

uspto-grants-1994_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05302595