Diisobutylaluminumhydride → HCID 86747751, compound

HRID 1463935Notes

Reaction equation

HRID 1463935 reaction equation
[CH2:1]1[CH2:22][O:21][CH:3]([CH2:4][C@H:5]2[C@H:12]([O:13][CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][O:15]3)[CH2:11][C@H:10]3[C@@H:6]2[CH2:7][C:8](=[O:20])[O:9]3)[O:2]1.[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[CH2:1]1[CH2:22][O:21][CH:3]([CH2:4][CH:5]2[CH:12]([O:13][CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][O:15]3)[CH2:11][CH:10]3[CH:6]2[CH2:7][CH:8]([OH:20])[O:9]3)[O:2]1

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 86746996HCID 86746996, compound

Product 1

HCID 86747751HCID 86747751, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The ether (57) (4.700 g) was reduced in toluene (80 ml) at -78° C. with diisobutylaluminum hydride (1.5-M, 12 ml) to give the lactol (58).

Sources & evidence

ORD record
ord-400ff5d6789141b7a2b4c95548edbf20
Source dataset
uspto-grants-1994_04
Patent number
US05302617

Reaction notes

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