Diazomethane → HCID 86747753, compound

HRID 1463937Notes

Reaction equation

HRID 1463937 reaction equation
[CH2:1]1[CH2:28][O:27][CH:3]([CH2:4][C@H:5]2[C@H:9]([O:10][CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][O:12]3)[CH2:8][C@H:7]([OH:17])[C@@H:6]2[CH2:18]/[CH:19]=[CH:20]\[CH2:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])[O:2]1.[N+](=[CH2:31])=[N-]>CCOCC>[CH2:28]1[CH2:1][O:2][CH:3]([CH2:4][C@H:5]2[C@H:9]([O:10][CH:11]3[CH2:16][CH2:15][CH2:14][CH2:13][O:12]3)[CH2:8][C@H:7]([OH:17])[C@@H:6]2[CH2:18]/[CH:19]=[CH:20]\[CH2:21][CH2:22][CH2:23][C:24]([O:26][CH3:31])=[O:25])[O:27]1

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 86747752HCID 86747752, compound

Product 1

HCID 86747753HCID 86747753, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The carboxylic acid (59) was treated with diazomethane in ether (150 ml) to give the methyl ester (60). The crude product obtained after the work-up was chromatographed on a column of silica gel (hexane/ethyl acetate =3/2).

Sources & evidence

ORD record
ord-343372d449c543479508cdab6a3ca08d
Source dataset
uspto-grants-1994_04
Patent number
US05302617

Reaction notes

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