反应详情

Methylation of the phenolic --OH group in (12) with MeI-K2CO3 in refluxing acetone proceed smoothly to give 2,4-dimethoxy-3-iodobenzaldehyde (13), m.p. 103.3° C. [1H-NMR: (90 MHz, CDCl3, δ): 3.90 (overlapping s, 2×3H, C2 and C4-OCH3), 6.62 and 7.78 (pair of doublets. Jab=8Hz, C5-H and C6-H), 10.12 (s, 1H, HC=O).]