HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydroxy-3-iodo-4-methoxybenzaldehyde → 2,4-Dimethoxy-3-iodobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydroxy-3-iodo-4-methoxybenzaldehyde | HCID 19089057 | — |
| Reactant | Methyl iodide potassium carbonate | HCID 86747754 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2,4-Dimethoxy-3-iodobenzaldehyde | HCID 19089056 | — |
Reaction Steps
Methylation of the phenolic --OH group in (12) with MeI-K2CO3 in refluxing acetone proceed smoothly to give 2,4-dimethoxy-3-iodobenzaldehyde (13), m.p. 103.3° C. [1H-NMR: (90 MHz, CDCl3, δ): 3.90 (overlapping s, 2×3H, C2 and C4-OCH3), 6.62 and 7.78 (pair of doublets. Jab=8Hz, C5-H and C6-H), 10.12 (s, 1H, HC=O).]
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05302700 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-e0c2b7068d394f0ab67af7e4b41fab8c |
| Source note | uspto-grants-1994_04 |