Bromotrimethylsilane → HCID 15780118, compound

HRID 1463971Notes

Reaction equation

HRID 1463971 reaction equation
[C:1]([CH2:5][CH2:6][C:7]([NH:9][CH:10]([P:14](=[O:19])([O:17]C)[O:15]C)[CH:11]([CH3:13])[CH3:12])=[O:8])([O:3][CH3:4])=[O:2].C[Si](Br)(C)C>C(Cl)Cl>[C:1]([CH2:5][CH2:6][C:7]([NH:9][CH:10]([P:14](=[O:15])([OH:19])[OH:17])[CH:11]([CH3:13])[CH3:12])=[O:8])([O:3][CH3:4])=[O:2]

Participants

4

Reactant 2

HCID 76113BromotrimethylsilaneHCID 15780123HCID 15780123, compound

Product 1

HCID 15780118HCID 15780118, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of a compound of formula 4, preferably dimethyl [1-[N-(3-carbomethoxypropionyl)amino]-2-methylpropyl]phosphonate, in an anhydrous polar aprotic solvent, such as methylene chloride, under an inert atmosphere, such as argon, is added trimethylsilyl bromide. The reaction is allowed to stir until complete. The product, a compound of formula 5, preferably [1-[N-(3-carbomethoxypropionyl)amino]-2-methylpropyl]phosphonic acid, may be isolated and purified by conventional means.

Sources & evidence

ORD record
ord-b87a40579f924f52bb94b1382ec6707f
Source dataset
uspto-grants-1994_04
Patent number
US05302707

Reaction notes

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