Bromotrimethylsilane → HCID 15780118, compound

Participants

Reaction Steps

To a solution of a compound of formula 4, preferably dimethyl [1-[N-(3-carbomethoxypropionyl)amino]-2-methylpropyl]phosphonate, in an anhydrous polar aprotic solvent, such as methylene chloride, under an inert atmosphere, such as argon, is added trimethylsilyl bromide. The reaction is allowed to stir until complete. The product, a compound of formula 5, preferably [1-[N-(3-carbomethoxypropionyl)amino]-2-methylpropyl]phosphonic acid, may be isolated and purified by conventional means.

Provenance & Evidence