Methyl iodide → HCID 543170, compound

Participants

Reaction Steps

To a suspension of 62% sodium hydride (0.36 g) in N,N-dimethylformamide (6 ml) was added 1H-imidazo[1,2-b]-pyrazole (1 g) under ice-cooling Then, thereto was added dropwise methyl iodide (0.58 ml) at the same temperature After the mixture was stirred at room temperature for 4 hours, ethyl acetate was added thereto The precipitate was filtered off, and the organic solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel to give 1-methyl-1H-imidazo-[1,2-b]pyrazole (0.9 g).

Provenance & Evidence