Methyl iodide → HCID 543170, compound

HRID 1463980Notes

Reaction equation

HRID 1463980 reaction equation
[H-].[Na+].[NH:3]1[C:10]2[N:6]([N:7]=[CH:8][CH:9]=2)[CH:5]=[CH:4]1.CI.[C:13](OCC)(=O)C>CN(C)C=O>[CH3:13][N:3]1[C:10]2[N:6]([N:7]=[CH:8][CH:9]=2)[CH:5]=[CH:4]1

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 8857Ethyl AcetateHCID 24758Sodium hydrideHCID 178419859HCID 178419859, compound

Product 1

HCID 543170HCID 543170, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a suspension of 62% sodium hydride (0.36 g) in N,N-dimethylformamide (6 ml) was added 1H-imidazo[1,2-b]-pyrazole (1 g) under ice-cooling Then, thereto was added dropwise methyl iodide (0.58 ml) at the same temperature After the mixture was stirred at room temperature for 4 hours, ethyl acetate was added thereto The precipitate was filtered off, and the organic solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel to give 1-methyl-1H-imidazo-[1,2-b]pyrazole (0.9 g).

Workup

  1. temperaturecooling
  2. filtrationThe precipitate was filtered off
  3. customthe organic solvent was evaporated in vacuo
  4. customThe residue was purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-2ca300d4563f4c559ef0f6bf5d88920e
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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