Ammonium Hydroxide → HCID 19089100, compound

HRID 1463988Notes

Reaction equation

HRID 1463988 reaction equation
C([O:3][C:4]([CH2:6][N:7]1[C:14]2[N:10]([N:11]=[CH:12][CH:13]=2)[CH:9]=[CH:8]1)=O)C.[OH-].[NH4+:16]>C(O)C>[C:4]([CH2:6][N:7]1[C:14]2[N:10]([N:11]=[CH:12][CH:13]=2)[CH:9]=[CH:8]1)(=[O:3])[NH2:16]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 19089097HCID 19089097, compound

Product 1

HCID 19089100HCID 19089100, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-ethoxycarbonylmethyl-1H-imidazo-[1,2-b]pyrazole (35 g) in ethanol (180 ml) was added 28% ammonium hydroxide solution (110 ml). The mixture was stirred at room temperature for two hours. The resultant precipitate was collected by filtration, washed with isopropyl ether and dried to give 1-carbamoylmethyl-1H-imidazo[1,2-b]pyrazole (18.0 g).

Workup

  1. filtrationThe resultant precipitate was collected by filtration
  2. washwashed with isopropyl ether
  3. customdried

Sources & evidence

ORD record
ord-55130b94406a433dbb7f0354d3de644e
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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