5-Amino-4-cyano-1-(2,2-diethoxyethyl)pyrazole → HCID 178510452, compound

HRID 1463992Notes

Reaction equation

HRID 1463992 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][CH:8](OCC)OCC)[N:5]=[CH:4][C:3]=1[C:15]#[N:16]>Cl>[C:15]([C:3]1[CH:4]=[N:5][N:6]2[CH:7]=[CH:8][NH:1][C:2]=12)#[N:16]

Participants

3

Reactant 1

HCID 3402435-Amino-4-cyano-1-(2,2-diethoxyethyl)pyrazole

Product 1

HCID 178510452HCID 178510452, compoundYield 91.5%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 5-amino-4-cyano-1-(2,2-diethoxyethyl)-pyrazole (23 g) in lN hydrochloric acid (205 ml) was heated at 60-70° C. The mixture was stirred for 0.5 hour at the same condition. The reaction mixture was cooled under ice-water and the resultant solid was collected by filtration, washed with ice-water and dried over phosphorus pentoxide in vacuo to the crude product. The product was crystallized from ethanol (400 ml) to give 7-cyano-1H-imidazo[1,2-b]pyrazole (12.4 g).

Workup

  1. temperatureThe reaction mixture was cooled under ice-water
  2. filtrationthe resultant solid was collected by filtration
  3. washwashed with ice-water
  4. dry with materialdried over phosphorus pentoxide in vacuo to the crude product
  5. customThe product was crystallized from ethanol (400 ml)

Sources & evidence

ORD record
ord-806a4b9853b14ac08d31828d0ab77216
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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