Sulfuric Acid → HCID 178513770, compound

HRID 1463993Notes

Reaction equation

HRID 1463993 reaction equation
[C:1]([C:3]1[CH:7]=[N:6][N:5]2[CH:8]=[CH:9][NH:10][C:4]=12)#[N:2].S(=O)(=O)(O)[OH:12].[OH-].[NH4+]>>[C:1]([C:3]1[CH:7]=[N:6][N:5]2[CH:8]=[CH:9][NH:10][C:4]=12)(=[O:12])[NH2:2]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 14923Ammonium HydroxideHCID 178510452HCID 178510452, compound

Product 1

HCID 178513770HCID 178513770, compound

Procedure

7-Cyano-1H-imidazo[1,2-b]pyrazole (3 g) was added to conc. sulfuric acid under ice-cooling. The mixture was stirred at room temperature for 45 minutes. The reaction mixture was cooled at 0°-5° C. and carefully poured into ice water (30 ml). The aqueous solution was neutralized with conc. ammonium hydroxide solution and stirred for 1 hour under ice-cooling. The precipitate was collected, washed with cold water and dried over phosphorus pentoxide in vacuo to give 7-carbamoyl-1H-imidazo[1,2-b]pyrazole (3.45 g).

Workup

  1. temperaturecooling
  2. temperatureThe reaction mixture was cooled at 0°-5° C.
  3. stirringstirred for 1 hour under ice-
  4. temperaturecooling
  5. customThe precipitate was collected
  6. washwashed with cold water
  7. dry with materialdried over phosphorus pentoxide in vacuo

Sources & evidence

ORD record
ord-afc2ac3a6f5b4b55ba083e0a8bd32e39
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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