Water → HCID 19089108, compound

Participants

Reaction Steps

Triphenylmethyl chloride (154.98 g) was added to a solution of triethylamine (154.97 ml) and 1-methoxycarbonylmethyl-5-aminopyrazole (71.88 g) in tetrahydrofuran (215.64 ml) and the mixture was stirred for three hours at ambient temperature. The reaction mixture was added to a mixture of water (300 ml) and ethyl acetate (200 ml). The organic layer was separated and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-methoxycarbonylmethyl-5-triphenylmethylaminopyrazole.

Provenance & Evidence