Water → HCID 19089108, compound

HRID 1463996Notes

Reaction equation

HRID 1463996 reaction equation
[C:1]1([C:7](Cl)([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[CH3:28][O:29][C:30]([CH2:32][N:33]1[C:37]([NH2:38])=[CH:36][CH:35]=[N:34]1)=[O:31].O>O1CCCC1.C(OCC)(=O)C>[CH3:28][O:29][C:30]([CH2:32][N:33]1[C:37]([NH:38][C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:36][CH:35]=[N:34]1)=[O:31]

Participants

7

Reactant 4

HCID 962WaterHCID 6456Trityl chlorideHCID 8471TriethylamineHCID 19089092Methyl 5-amino-1H-pyrazole-1-acetate

Product 1

HCID 19089108HCID 19089108, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

Triphenylmethyl chloride (154.98 g) was added to a solution of triethylamine (154.97 ml) and 1-methoxycarbonylmethyl-5-aminopyrazole (71.88 g) in tetrahydrofuran (215.64 ml) and the mixture was stirred for three hours at ambient temperature. The reaction mixture was added to a mixture of water (300 ml) and ethyl acetate (200 ml). The organic layer was separated and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-methoxycarbonylmethyl-5-triphenylmethylaminopyrazole.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe magnesium sulfate was filtered off
  4. customthe filtrate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-a2303d4e978042b19355179194312bea
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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