2-Aminobiphenyl → HCID 178511973, compound

HRID 1464031Notes

Reaction equation

HRID 1464031 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH:14]1([C:20]#[N:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.[Cl-].[Al+3].[Cl-].[Cl-]>>[C:3]1([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:20]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[NH:21]

Participants

4

Reactant 3

HCID 70152-AminobiphenylHCID 69834CyanocyclohexaneHCID 6451240Aluminum(III) Chloride

Product 1

HCID 178511973HCID 178511973, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 2-aminobiphenyl (3.4 g), cyclohexane carbonitrile (6.5 g) and anhydrous aluminium chloride (8 g) was heated at 100° C. for 8 hours then at 120° C. for 8 hours to yield a product which was purified by chromatography on a neutral alumina column which was eluted with dichloromethane to give N-(2-biphenylyl)-cyclohexane-1-carboxamidine (m.p. 148°-150° C.).

Workup

  1. customat 120° C. for 8 hours to yield a product which
  2. customwas purified by chromatography on a neutral alumina column which
  3. washwas eluted with dichloromethane

Sources & evidence

ORD record
ord-e7fc1b95cebc4a0684120a32b4005fba
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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