2-Aminobiphenyl → 1-Isothiocyanato-2-phenylbenzene

HRID 1464032Notes

Reaction equation

HRID 1464032 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[C:14](Cl)(Cl)=[S:15].O1CCOCC1>O>[C:3]1([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:2]([N:1]=[C:14]=[S:15])=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 70152-AminobiphenylHCID 10040ThiophosgeneHCID 312751,4-Dioxane

Product 1

HCID 5196591-Isothiocyanato-2-phenylbenzene

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

A mixture of 2-aminobiphenyl (10.2 g), thiophosgene (10.4 g), dioxane (50 ml) and water (100 ml) was prepared with cooling in an ice bath. The temperature was raised to 30° C. and stirred for 3 hours at 30° C. to yield 2-biphenylylisothiocyanate as a yellow oil.

Workup

  1. customwas prepared
  2. temperaturewith cooling in an ice bath

Sources & evidence

ORD record
ord-2cccb94890904c5bb3b50d93810f8a12
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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