Methylamine → HCID 23170259, compound

Participants

Reaction Steps

A mixture of 1-(2-biphenylyl)-2,3-dimethyl-2-thiopseudourea hydriodide (7 g) and a 33% solution of methylamine in ethanol (250 ml) was stirred at ambient temperature for 56 days to give N-(2-biphenylyl)-N',N"-dimethylguanidine (m.p. 101°-102° C.) which was recrystallised from hexane. A sample (2.4 g) was dissolved in methanol (25 ml) and treated with fumaric acid (1.16 g) to give N-(2-biphenylyl)-N',N"-dimethylguanidine fumarate (m.p. 192°-193° C.) which was recrystallised from propan-2-ol.

Provenance & Evidence