Piperidinocarbonitrile → HCID 178492304, compound

HRID 1464044Notes

Reaction equation

HRID 1464044 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:17]([N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)#[N:18]>C1C(O)=CC=CC=1C>[CH3:10][O:9][C:6]1[CH:7]=[CH:8][C:3]([NH:2][C:17]([N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[NH:18])=[C:4]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 73736PiperidinocarbonitrileHCID 190892652-Amino-5-methoxybiphenyl hydrochloride

Product 1

HCID 178492304HCID 178492304, compound

Reagents, catalysts & solvents 1

HCID 342M-CresolSolvent

Procedure

2-Amino-5-methoxybiphenyl hydrochloride (0.9 g) was heated with N-cyanopiperidine (0.45 g) in m-cresol (1 ml) at 140° C. for 8 hours to give N-(5-methoxy-2-biphenylyl)piperidine-1-carboxamidine which was crystallised from a 1:9 mixture of ethylacetate and hexane to furnish N-(5-methoxy-2-biphenylyl)piperidine-1-carboxamidine as a pale brown crystals (m.p. 155° C.).

Sources & evidence

ORD record
ord-01d79bdc760e460d8e4cb30624429e21
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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