M-Cresol → HCID 178424491, compound

HRID 1464045Notes

Reaction equation

Cl.[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH3:15])[CH:10]=1.[C:16]([N:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)#[N:17].C1C(O)=CC=CC=1C>>[CH3:15][C:11]1[CH:10]=[C:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[NH:2][C:16]([N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[NH:17])[CH:14]=[CH:13][CH:12]=1

Participants

Reactant 3

HCID 342M-Cresol

HCID 73736Piperidinocarbonitrile

HCID 27598232-Amino-3'-methylbiphenyl hydrochloride

Product 1

HCID 178424491HCID 178424491, compound

Conditions

Temperature: 100 °C

Procedure

A mixture of 2-amino-3'-methylbiphenyl hydrochloride (1.09 g), N-cyanopiperidine (0.6 g) and m-cresol (0.5 ml) was heated at 100° C. for 3 hours to give N-(3'-methyl-2-biphenylyl)piperidine-1-carboxamidine (m.p. 131° C.).

Sources & evidence

ORD record: ord-c09cecaf36a44cbb812e43539fadb088
Source dataset: uspto-grants-1994_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05302720

Reaction notes

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