Piperidinocarbonitrile → HCID 178504668, compound

HRID 1464048Notes

Reaction equation

HRID 1464048 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][CH:10]=1.[C:19]([N:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)#[N:20]>C1C(O)=CC=CC=1C>[CH3:18][S:15]([C:12]1[CH:13]=[CH:14][C:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[NH:2][C:19]([N:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[NH:20])=[CH:10][CH:11]=1)(=[O:17])=[O:16]

Participants

4

Reactant 2

HCID 73736PiperidinocarbonitrileHCID 190892704'-(Methylsulfonyl)-[1,1'-biphenyl]-2-amine hydrochloride

Product 1

HCID 178504668HCID 178504668, compound

Reagents, catalysts & solvents 1

HCID 342M-CresolSolvent

Procedure

A mixture of 2-amino-4'-methanesulphonylbiphenyl hydrochloride (2.3 g), N-cyanopiperidine (1.3 g) and m-cresol (10 ml) was heated at 90°-95° C. for 10 hours to give N-(4'-methanesulphonyl-2-biphenylyl)piperidine-1-carboxamidine (m.p. 128°-129° C.) which was recrystallised from hexane.

Workup

  1. temperaturewas heated at 90°-95° C. for 10 hours

Sources & evidence

ORD record
ord-eafb3ef557c04c31b7b45b2140f0d308
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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