4-Morpholinecarbonitrile → HCID 178423713, compound

HRID 1464049Notes

Reaction equation

HRID 1464049 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[CH:5][C:4]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[C:16]([N:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1)#[N:17]>C1C(O)=CC=CC=1C>[CH3:9][C:7]1[CH:6]=[CH:5][C:4]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[C:3]([NH:2][C:16]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[NH:17])[CH:8]=1

Participants

4

Reactant 2

HCID 737384-MorpholinecarbonitrileHCID 190892224-Methyl[1,1'-biphenyl]-2-amine--hydrogen chloride (1/1)

Product 1

HCID 178423713HCID 178423713, compound

Reagents, catalysts & solvents 1

HCID 342M-CresolSolvent

Procedure

A mixture of 2-amino-4-methylbiphenyl hydrochloride (7.7 g) and 4-cyanomorpholine (5.9 g) in m-cresol (45 ml) was heated at 90°-95° C. for 15 hours to yield N-(4-methyl-2-biphenylyl)morpholine-4-carboxamidine (m.p. 154°-155° C.) which was recrystallised from hexane.

Workup

  1. temperaturewas heated at 90°-95° C. for 15 hours

Sources & evidence

ORD record
ord-05da2ece5cf0427fb5a2b97bd7992940
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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